The molecular mechanisms underlying nephrotic syndrome (NS) are unknown. In this three-way collaboration between Duke University (primary), University of Miami, and University of Michigan, we will examine the role of genetic defects in RCAN1 and other genes in the calcineurin signaling pathways in the pathogenesis of NS, identify predictors of response to calcineurin inhibitors, and new therapeutic targets for NS. We are excited to bring the drug discovery technologies of the Ali lab to bear on nephrotic syndrome with world-class experts in this area!
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Recent Posts
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Colin Kelley (ex. NCATS) and Omar El-wardany (practicing neurosurgeon) have joined our team and will help us power up our drug discovery operations. Colin will lead some of our screening work while Om
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Super proud of our post doc Rachel Njeim for winning Oustanding Research Recognition Award at the International Podocyte Conference 2023. Next stop, small molecule therapeutic candidate for Diabetic K
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