The molecular mechanisms underlying nephrotic syndrome (NS) are unknown. In this three-way collaboration between Duke University (primary), University of Miami, and University of Michigan, we will examine the role of genetic defects in RCAN1 and other genes in the calcineurin signaling pathways in the pathogenesis of NS, identify predictors of response to calcineurin inhibitors, and new therapeutic targets for NS. We are excited to bring the drug discovery technologies of the Ali lab to bear on nephrotic syndrome with world-class experts in this area!
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